A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

  • Umbrias@beehaw.org
    link
    fedilink
    arrow-up
    42
    ·
    1 year ago

    You just don’t digest as much nor store as much calories. So your feces and urine, as well as exhalation.

    It’s not cheating basic physics, there’s just a lot of misunderstanding about how weight works in biology. Cico is not what many people believe it to be.

    • Natanael@slrpnk.net
      link
      fedilink
      arrow-up
      6
      ·
      1 year ago

      Absorbed calories in spent calories out would be more accurate, but nobody wants to do the more complicated math.

      And some processes can technically be calorie neutral and still affect weight (like say how much water we hold)