I went IPv6-only for everything internal. The only thing that’s dual stack is the wireguard server running on the gateway. I haven’t run into any issues, mostly because my Linux distro’s package repository has many IPv6-compatible mirrors (enabled by default). For anything not in the distro’s repos, I build from source and package them up into RPMs myself, so as a side-effect, I don’t have to deal with eg. Github not supporting IPv6.
Even things with generally crappy firmware, like the APC UPS management card, Supermicro & ASRock IPMI management interfaces, etc. have worked fine in an IPv6-only setup for me.
For the most part, these distros all require that packages are built from source vs. repackaging prebuilt binaries. While Brave is open source, if you compile it yourself, you’ll be missing tons of API keys for accessing Brave’s services: https://github.com/brave/brave-browser/wiki/Build-configuration. While I suspect most folks wouldn’t care if eg. the cryptocurrency things stopped working, other things that break include Brave Sync and the downloading of the adblocker filter lists.
Brave currently does not provide a way for 3rd parties to generate API keys to access these services: https://community.brave.com/t/does-brave-allow-the-distribution-of-self-compiled-or-distro-compiled-binaries/457833. Outside of reverse engineering their prebuilt binaries to extract the API keys, you’re pretty much out of luck (if you care about these features working).
For websites that only work in Chromium, I’ve switched to just using plain old Chromium from Fedora’s repos. Being able to build the browser from source without losing features is pretty important to me (eg. I rebuild Fedora’s Chromium with the patches for enabling hardware video decoding on Wayland).